Accepting PatientsPhase 3 (Comparison)NCT06632444

LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis

Metabolic Dysfunction Associated Steatohepatitis (MASH), Liver Fibrosis

Phase:Phase 3 (Comparison)

Status:Accepting Patients

Age:18+

Gender:All

Locations:530 sites

What This Study Is About

This study is open to adults who are at least 18 years old living with obesity and have: * a confirmed liver disease called non-alcoholic steatohepatitis (NASH)/metabolic associated steatohepatitis (MASH) and * moderate or advanced liver fibrosis People with a history of acute or chronic liver diseases other than MASH or chronic alcohol intake cannot take part in this study. The purpose of this study is to find out whether a medicine called survodutide helps people with MASH and moderate or advanced liver fibrosis improve their liver function. This study has 2 parts. The purpose of the first part of this study is to find out the effect of survodutide on MASH and liver fibrosis. The purpose of the second part is to find out how safe and effective survodutide is in improving liver function. Participants are put into 2 groups randomly, which means by chance. 1 group gets survodutide and 1 group gets placebo. Placebo looks like survodutide but does not contain any medicine. Each participant has twice the chance of getting survodutide. Participants and doctors do not know who is in which group. Participants inject survodutide or placebo under their skin once a week. The survodutide doses are slowly increased until the target dose is reached. All participants receive counselling to make changes to their diet and to exercise regularly. Participants are in the study for up to 7 years. During this time, they regularly visit the study site or have remote visits by video call. For about the first year of the study, participants have these visits every 2 weeks, increasing to every 4 weeks and then every 6 weeks. After being in the study for a little over a year participants will then alternate between visiting the study site or having a remote visit every 3 months until the end of the study. The doctors check participants' health and take note of any unwanted effects. The participants' body weight and effects on the stomach and intestines are regularly measured. At some visits the liver is measured using different imaging methods. At 2 or 3 visits doctors take a small sample of liver tissue (biopsy). The participants also fill in questionnaires about their symptoms and quality of life. The results are compared between the groups to see whether the treatment works.

Who Can Participate

You May Qualify If

Male or female participants ≥18 years (or who are of legal age in countries where that is greater than 18 years) of age at time of consent
Diagnosis of MASH (non-alcoholic fatty liver disease (NAFLD)) activity score \[NAS\] ≥4
Stable body weight defined as less than 5% self-reported change in body weight 3 months prior to the screening or during the period between the historical biopsy and randomisation, if a historical biopsy is used

You Cannot Join If

Any of the following liver laboratory test abnormalities at screening:
Alkaline phosphatase \>2x upper limit of normal (ULN)
Abnormal synthetic liver function as defined by screening central laboratory evaluation:
Albumin below \<3.5 g/dL (35.0 g/L)
OR International normalised ratio (INR) of prothrombin time \>1.3
+4 more...

Discuss With Your Doctor

Serum AST and/or alanine aminotransferase (ALT) elevation ≥5x upper limit of normal (ULN)
Platelet count \<140 000/mm\^3 (\<140 GI/L)
Any history or evidence of acute or chronic liver disease other than MASH
Histologically documented liver cirrhosis (fibrosis stage F4), either at screening or in a historical biopsy
History of portal hypertension or presence of decompensated liver disease

Key Requirements

Age 18+ years

View Full Eligibility Criteria

Full Criteria (from ClinicalTrials.gov)

Inclusion criteria: 1. Male or female participants ≥18 years (or who are of legal age in countries where that is greater than 18 years) of age at time of consent 2. Diagnosis of MASH (non-alcoholic fatty liver disease (NAFLD)) activity score \[NAS\] ≥4 3. Stable body weight defined as less than 5% self-reported change in body weight 3 months prior to the screening or during the period between the historical biopsy and randomisation, if a historical biopsy is used 4. Be willing to maintain a stable diet and physical activity levels throughout the entire trial Further inclusion criteria apply Exclusion criteria: 1. Any of the following liver laboratory test abnormalities at screening: * Serum AST and/or alanine aminotransferase (ALT) elevation ≥5x upper limit of normal (ULN) * Platelet count \<140 000/mm\^3 (\<140 GI/L) * Alkaline phosphatase \>2x upper limit of normal (ULN) * Abnormal synthetic liver function as defined by screening central laboratory evaluation: * Albumin below \<3.5 g/dL (35.0 g/L) * OR International normalised ratio (INR) of prothrombin time \>1.3 * OR total serum bilirubin concentration ≥1.5x ULN 2. Any history or evidence of acute or chronic liver disease other than MASH 3. Histologically documented liver cirrhosis (fibrosis stage F4), either at screening or in a historical biopsy 4. History of or current diagnosis of hepatocellular carcinoma 5. History of or planned liver transplant 6. Inability or unwillingness to undergo a liver biopsy at screening (if a suitable historical biopsy is unavailable for central review), or during trial conduct. 7. History of portal hypertension or presence of decompensated liver disease 8. Model for end-stage liver disease (MELD) score ≥12 due to liver disease. Further exclusion criteria apply

Important: This is a summary. The final determination of eligibility will be made by the trial coordinator after reviewing your complete medical history.

Study Locations

University of Alabama at Birmingham — Birmingham, Alabama

The Institute for Liver Health II DBA Arizona Clinical Trials — Peoria, Arizona

Scottsdale Medical Specialists, Ltd — Scottsdale, Arizona

Show all 530 locations

Adobe Clinical Research, LLC — Tucson, Arizona

Arizona Liver Health - Tucson — Tucson, Arizona

Del Sol Research Management, LLC — Tucson, Arizona

Hope Clinical Research — Canoga Park, California

Velocity Clinical Research-Chula Vista — Chula Vista, California

Southern California Research Center — Coronado, California

ARK Clinical Research — Fountain Valley, California

Fresno Clinical Research Center — Fresno, California

Velocity Clinical Research-Gardena-69773 — Gardena, California

Velocity Clinical Research-Huntington Park — Huntington Park, California

310 Clinical Research — Inglewood, California

Velocity Clinical Research, San Diego — La Mesa, California

Om Research, LLC — Lancaster, California

ARK Clinical Research — Long Beach, California

Velocity Clinical Research, Westlake — Los Angeles, California

Catalina Research Institute, LLC — Montclair, California

Clinnova Research Solutions — Orange, California

Fomat Medical Research — Oxnard, California

California Liver Research Institute — Pasadena, California

Cadena Care Institute, LLC — Poway, California

Ficramed Research Institute — Poway, California

Inland Empire Clinical Trials, LLC — Rialto, California

Metro Clinical Trials — San Bernardino, California

Acclaim Clinical Research — San Diego, California

Medical Associates Research Group, Inc. — San Diego, California

Velocity Clinical Research, Santa Ana — Santa Ana, California

Velocity Clinical Research, Van Nuys — Van Nuys, California

Om Research, LLC — Victorville, California

Future Innovative Treatments — Colorado Springs, Colorado

South Denver Gastroenterology PC — Englewood, Colorado

Connecticut Gastroenterology Clinical Research Foundation — Bristol, Connecticut

Yale University School of Medicine — New Haven, Connecticut

OMEGA Research Group — Altamonte Springs, Florida

Synergy Healthcare — Bradenton, Florida

Synergy Healthcare of Tampa — Brandon, Florida

Access research Institute — Brooksville, Florida

Tampa Bay Medical Research — Clearwater, Florida

K2 Medical Research - Winter Garden — Clermont, Florida

Hi Tech and Global Research, LLC — Coral Gables, Florida

Cenara Clinical Research — Cutler Bay, Florida

Covenant Metabolic Specialists, LLC - Fort Myers — Fort Myers, Florida

University of Florida — Gainesville, Florida

Neoclinical Research — Hialeah, Florida

Evolution Clinical Trials — Hialeah Gardens, Florida

Global Research Associates — Homestead, Florida

Lake Center for Clinical Research — Lady Lake, Florida

Florida Research Institute — Lakewood Rch, Florida

K2 Medical Research — Maitland, Florida

Research Associates of South Florida, LLC — Miami, Florida

Optimus U Corporation-Miami-69452 — Miami, Florida

Schiff Center Liver Diseases — Miami, Florida

BioMed Research & Medical Center — Miami, Florida

ECIR Miami Holdings LLC dba IMIC — Miami, Florida

Entrust Clinical Research — Miami, Florida

Floridian Clinical Research — Miami Lakes, Florida

GI Pros Research — Naples, Florida

Charter Research — Orlando, Florida

K2 Medical Research — Orlando, Florida

Endoscopic Research, Inc — Orlando, Florida

Innovation Medical Research Center — Palmetto Bay, Florida

MplusM - Best Choice Medical and Research Service — Pembroke Pines, Florida

Progressive Medical Research — Port Orange, Florida

Covenant Metabolic Specialist, LLC - Riverview — Riverview, Florida

Global Clinical Professionals — St. Petersburg, Florida

International Center for Research — Tampa, Florida

Charter Research — The Villages, Florida

Covenant Metabolic Specialists, LLC - University Park — University Park, Florida

Conquest Research — Winter Park, Florida

Florida Medical Clinic, P.A. — Zephyrhills, Florida

Gastroenterology Associates of Central Georgia — Macon, Georgia

EmVenio Research Center at Prime Healthcare - Riverdale — Riverdale, Georgia

ASHA Clinical Research - Munster, LLC — Hammond, Indiana

Digestive Research Alliance of Michiana — South Bend, Indiana

Iowa Digestive Disease Center — Clive, Iowa

Iowa Diabetes and Endocrinology Research Center — West Des Moines, Iowa

University of Kansas Medical Center — Kansas City, Kansas

Kansas Medical Clinic PA — Topeka, Kansas

Delta Research Partners, LLC — Bastrop, Louisiana

Tandem Clinical Research — Marrero, Louisiana

Louisiana Research Center, LLC — Shreveport, Louisiana

Mercy Medical Center — Baltimore, Maryland

Boston Medical Center — Boston, Massachusetts

Clinical Research Institute of Michigan, LLC — Clinton Township, Michigan

West Michigan Clinical Research Center — Wyoming, Michigan

MNGI Digestive Health, PA — Minneapolis, Minnesota

Gastrointestinal Associates, PA — Flowood, Mississippi

Clinical Research Professionals — Chesterfield, Missouri

ObjectiveHealth-GI Associates Research — Columbia, Missouri

Kansas City Research Institute — Kansas City, Missouri

University of Nebraska Medical Center — Omaha, Nebraska

Jubilee Clinical Research, Inc — Las Vegas, Nevada

Excel Clinical Research — Las Vegas, Nevada

Clinical Research of South Nevada — Las Vegas, Nevada

IMA Clinical Research-Warren-69742 — Warren Township, New Jersey

NewYork-Presbyterian Brooklyn Methodist Hospital — Brooklyn, New York

Basil Clinical — Laurelton, New York

Icahn School of Medicine at Mount Sinai — New York, New York

University of Rochester Medical Center — Rochester, New York

Duke University Medical Center — Durham, North Carolina

Coastal Research Institute, LLC — Fayetteville, North Carolina

Carolina Researche — Greenville, North Carolina

Centricity Research (New Bern) — New Bern, North Carolina

M3 Wake Research, Inc. — Raleigh, North Carolina

The Ohio State University Wexner Medical Center — Columbus, Ohio

Great Lakes Gastroenterology — Mentor, Ohio

ObjectiveHealth-DSI Research - Springboro, LLC — Springboro, Ohio

Northshore Gastroenterology Research — Westlake, Ohio

Options Health Research — Tulsa, Oklahoma

US Digestive Health — Flourtown, Pennsylvania

Penn State Milton S. Hershey Medical Center — Hershey, Pennsylvania

US Digestive Health — Lancaster, Pennsylvania

Geisinger Health — State College, Pennsylvania

US Digestive Health — Wyomissing, Pennsylvania

Medical University of South Carolina — Charleston, South Carolina

ObjectiveHealth-Columbia Digestive Health Research — Columbia, South Carolina

Palmetto Clinical Research — Summerville, South Carolina

ClinSearch, LLC — Chattanooga, Tennessee

Innovative Clinical Research — Clarksville, Tennessee

Vanderbilt University Medical Center — Nashville, Tennessee

Texas Clinical Research Institute, LLC — Arlington, Texas

IMA Clinical Research Austin — Austin, Texas

American Research Corporation - Austin — Austin, Texas

Pinnacle Clinical Research - Austin — Austin, Texas

Velocity Clinical Research, Austin — Austin, Texas

Bellaire Clinical Research, LLC — Bellaire, Texas

South Texas Research Institute - Brownsville — Brownsville, Texas

Epic Medical Research - Carrollton — Carrollton, Texas

Pinnacle Clinical Research - Corpus Christi — Corpus Christi, Texas

North Texas Research Institute - Dallas — Dallas, Texas

Velocity Clinical Research-Dallas-69170 — Dallas, Texas

Zenos Clinical Research — Dallas, Texas

GI Alliance Research - Dallas — Dallas, Texas

Soma Clinical Trials — Denison, Texas

Epic Medical Research - DeSoto — DeSoto, Texas

South Texas Research Institute-Edinburg-67012 — Edinburg, Texas

Care United Research — Forney, Texas

EmVenio Research Center at Prime Healthcare - Farmers Branch — Garden City, Texas

Epic Medical Research - Garland — Garland, Texas

Pinnacle Clinical Research, LLC — Georgetown, Texas

HRI Medical Center — Houston, Texas

Ben Taub General Hospital — Houston, Texas

Biopharma Informatic, Inc. Research Center — Houston, Texas

Research Physicians Network — Houston, Texas

Epic Clinical Research — Lewisville, Texas

GI Alliance Research - Mansfield — Mansfield, Texas

Biopharma Informatic LLC — McAllen, Texas

Centex Studies, Inc. — McAllen, Texas

Epic Medical Research - Plano — Plano, Texas

American Research Corporation at the Texas Liver Institute — San Antonio, Texas

Brooke Army Medical Center — San Antonio, Texas

Pinnacle Clinical Research - San Antonio — San Antonio, Texas

Clinical Trials of Texas, LLC — San Antonio, Texas

Pinnacle Clinical Research, LLC — San Antonio, Texas

HASresearch — San Antonio, Texas

Velocity Clinical Research, Waco — Waco, Texas

Objective Health-Digestive Research of Central Texas — Waco, Texas

ObjectiveHealth-Digestive Health Research of North Texas — Wichita Falls, Texas

Liver Institute of Virginia-Bremo — Newport News, Virginia

GI Select Health Research, LLC — Richmond, Virginia

VCU Medical Center West Hospital — Richmond, Virginia

Velocity Clinical Research, Seattle — Seattle, Washington

Velocity Clinical Research-Spokane-69716 — Spokane, Washington

CIPREC — Buenos Aires

IDIM - Instituto de Diagnostico e Investigaciones Metabolicas — Buenos Aires

Centro de Investigaciones Metabolicas (CINME) — Buenos Aires

Buenos Aires Macula S.A. — Buenos Aires

Mautalen- Salud e Investigacion — Buenos Aires

Hospital Italiano de Buenos Aires — Buenos Aires

Glenny Corp - Centro Medico Saavedra — Buenos Aires

Hospital General de Agudos Dr. J. M. Ramos Mejia — Ciudad Autonoma Buenos Aires

Hospital Universitario Austral — Pilar

DIM Clinica Privada — Ramos Mejía

Hospital El Cruce — San Juan Bautista

Concord Repatriation General Hospital — Concord, New South Wales

Nepean Hospital — Kingswood, New South Wales

Liverpool Hospital — Liverpool, New South Wales

Westmead Hospital — Westmead, New South Wales

Sunshine Coast University Hospital — Birtinya, Queensland

Monash Health — Clayton, Victoria

Austin Health — Heidelberg, Victoria

Royal Melbourne Hospital — Parkville, Victoria

Royal Perth Hospital — Perth, Western Australia

Medical University of Graz — Graz

Ordensklinikum Linz GmbH — Linz

Klinik Landstrasse — Vienna

Medical University of Vienna — Vienna

Klinik Hietzing — Vienna

Klinikum Wels - Grieskirchen GmbH — Wels

Hopital Erasme — Brussels

Cliniques Universitaires Saint-Luc — Brussels

Universitair Ziekenhuis Antwerpen — Edegem

Ziekenhuis Oost-Limburg — Genk

Universitair Ziekenhuis Gent — Ghent

UZ Leuven — Leuven

Centre Hospitalier Universitaire de Liège — Liège

Clinique Saint-Luc Bouge — Namur

AZ Delta — Roeselare

Universidade Federal do Rio de Janeiro — Barra

Hospital Universitário João de Barros Barreto — Belém

Hospital das Clinicas da Universidade Federal de Minas Gerais (HC-UFMG) — Belo Horizonte

Universidade Estadual Paulista "Julio De Mesquita Filho" — Botucatu

Hospital das Clínicas da Faculdade de Medicina da USP — Cerqueira César

Centro de Pesquisa Clinica do Brasil — Lago Sul

Hospitalar Moinhos de Vento — Porto Alegre

Universidade Federal do Rio Grande do Sul — Porto Alegre

Hospital de Base — São José do Rio Preto

Rocco E Nazato Servicos Medicos LTDA — São Paulo

MHAT Sv. Ivan Rilski EOOD — Gorna Oryahovitsa

Multi-profile Hospital For Active Treatment-Uni Hospital Ltd. — Panagyurishte

Acibadem City Clinic Tokuda University Hospital EAD — Sofia

Diagnostic Consultative Center Alexandrovska — Sofia

University Multiprofile Hospital for Active Treatment St. Ivan Rilski EAD — Sofia

Medical Military Academy MHAT Sofia — Sofia

Medical Center New Rehabilitation Center EOOD — Stara Zagora

University of Calgary — Calgary, Alberta

University of British Columbia — Vancouver, British Columbia

Pacific Gastroenterology Associates — Vancouver, British Columbia

Viable Clinical Research — Bridgewater, Nova Scotia

Toronto Liver Centre — Toronto, Ontario

Centre Hospitalier de l'Universite de Montreal (CHUM) — Montreal, Quebec

McGill University Health Centre (MUHC) — Montreal, Quebec

Centre de Médecine Métabolique de Lanaudière — Terrebonne, Quebec

Diex Recherche Québec — Québec

Edificio Fleming — La Serena

Centro de Investigaciones Medicas UC — Santiago

Centro de Investigaciones Clinicas Viña del Mar — Viña del Mar

Beijing Ditan Hospital Capital Medical University — Beijing

Peking University People's Hospital — Beijing

Beijing Friendship Hospital — Beijing

Beijing Youan Hospital, Capital Medical University — Beijing

Beijing Tsinghua Changgung Hospital — Beijing

The First Hospital of Jilin University — Changchun

Hunan Provincial People's Hospital — Changsha

Xiangya Hospital, Central South University — Changsha

Changzhou Third People's Hospital — Changzhou Shi

West China Hospital, Sichuan University — Chengdu

Chongqing Three Gorges Central Hospital — Chongqing

The First People's Hospital of Foshan — Foshan

The First Affiliated Hospital of Fujian Medical University — Fuzhou

Mengchao Hepatobiliary Hospital of Fujian Medical University — Fuzhou

Guangzhou Eighth People's Hospital,Guangzhou Medical University — Guangzhou

Guangzhou First People's Hospital — Guangzhou

The First Affiliated Hospital,Sun Yat-sen University — Guangzhou

NanFang Hosptial — Guangzhou

The third affiliated hospital of Sun Yat-Sen University — Guangzhou

Guizhou Provincial People's Hospital — Guiyang

The First Affiliated Hospital, Zhejiang University — Hangzhou

Zhejiang Hospital — Hangzhou

The Affiliated Hospital of Hangzhou Normal University — Hangzhou

Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine — Hangzhou

The First Hospital of Jiaxing — Jiaxing

Liaocheng People's Hospital — Liaocheng

The First Affiliated Hospital of Henan University of Science and Technology — Luoyang

The First Affiliated Hospital of Nanchang University — Nanchang

The Second Affiliated Hospital to Nanchang University — Nanchang

The Second Hospital of Nanjing — Nanjing

Nanjing Drum Tower Hospital — Nanjing

Ningbo Second Hospital — Ningbo

General Hospital of Ningxia Medical University — Ningxia

Pingxiang People's Hospital — Pingxiang

Qingdao Municipal Hospital — Qingdao

Ruijin Hospital Shanghai Jiao Tong University School of Medicine — Shanghai

Huashan Hospital, Fudan University — Shanghai

Shanghai General Hospital — Shanghai

Shanghai East Hospital — Shanghai

Renji Hospital Shanghai Jiaotong University School of Medicine — Shanghai

Shanghai Public Health Clinical Center — Shanghai

The Sixth People's Hospital of Shenyang — Shenyang

The Third People's Hospital of Shenzhen — Shenzhen

The Fifth People's Hospital of Suzhou — Suzhou

Tianjin Third Central Hospital — Tianjin

Tianjin Second People's Hospital — Tianjin

The First Affiliated Hospital of Wenzhou Medical University — Wenzhou

Union Hospital Tongji Medical College Huazhong University of Science and Technology — Wuhan

Renmin Hospital of Wuhan University — Wuhan

Wuxi No. 5 People's Hospital — Wuxi

Second Affiliated Hospital of medical college of Xi'an JiaoTong University — Xi'an

First Affiliated Hospital of Xi'an JiaoTong University — Xi'an

The Affiliated Hospital of Xuzhou Medical College — Xuzhou

Yanbian University Hospital — Yanji

Yueyang Central Hospital — Yueyang

Yuncheng Center Hopsital — Yuncheng

Sixth People's Hospital of Zhengzhou — Zhengzhou

The Third People's Hospital of Zhenjiang — Zhenjiang

Krajska nemocnice Liberec a.s. — Liberec

Research Site s.r.o. — Pilsen

General Faculty Hospital, Prague — Prague

CHU Amiens-Picardie — Amiens

Centre Hospitalier Universitaire D'Angers — Angers

Hôpital Beaujon — Clichy

Hopital Henri Mondor — Créteil

HOP Dijon-Bourgogne — Dijon

Centre Hospitalier De Versailles — Le Chesnay

Hôpital Claude Huriez — Lille

Hopital De La Croix-Rousse — Lyon

Hôpital de l'Archet — Nice

Hopitaux Universitaires Pitié-Salpétrière — Paris

Hôpital Cochin — Paris

Centre Hospitalier Universitaire De Bordeaux — Pessac

Centre Hospitalier Lyon Sud — Pierre-Bénite

Hôpital Rangueil - CHU de Toulouse — Toulouse

Ltd "Health" — Batumi

ISR-GEO Med Res Clin Healthycore — Tbilisi

Charité - Universitätsmedizin Berlin — Berlin

Universitätsklinikum Knappschaftskrankenhaus Bochum GmbH — Bochum

Universitätsklinikum Köln (AöR) — Cologne

Technische Universität Dresden — Dresden

Universitätsklinikum Erlangen — Erlangen

Universitätsklinikum Frankfurt — Frankfurt

Universitätsklinikum Heidelberg — Heidelberg

Universität des Saarlandes — Homburg

Klinikum Landshut AdöR der Stadt Landshut — Landshut

Eugastro GmbH — Leipzig

Universitätsklinikum Schleswig-Holstein, Campus Lübeck — Lübeck

Otto-von-Guericke-Universität Magdeburg — Magdeburg

Universitätsmedizin der Johannes Gutenberg-Universität Mainz — Mainz

Universitätsklinikum Heidelberg — Mannheim

Universitätsklinikum Münster — Münster

Universitätsklinikum Tübingen — Tübingen

St. Josefs-Hospital Wiesbaden — Wiesbaden

Universitätsklinikum Würzburg AÖR — Würzburg

Dr. Rethy Pal Hospital — Békéscsaba

Obudai Egeszegugyi Centrum — Budapest

Semmelweis Egyetem Sebeszeti, Transzplantacios es Gasztroenterologiai Klinika — Budapest

Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet — Budapest

Aryav Superspeciality Hospital — Ahemdabad

Post Graduate Institute of Medical Education and Research — Chandigarh

Osmania Medical College & Hospital — Hyderabad, Afzalgunj

SR Kalla Memorial Hospital — Jaipur

ManglamPlus Medicity Hospital — Jaipur

Atharva Multispecialty Hospital and research Centre — Lucknow

Fortis Hospital, Mohali — Mohali

Midas Multispeciality Hospital Pvt. Ltd. — Nagpur

Insitute of Liver and Billiary Sciences — New Delhi

All India Institute of Medical Sciences — New Delhi

Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences — Rohtak

Yashoda Hospitals - Secunderabad — Secunderabad

Surat Institute of Digestive Sciences — Surat

BAPS Pramukh Swami Hospital — Surat

Gujarat Gastro and Vascular Hospital — Surat

Policlinico S. Orsola-Malpighi — Bologna

Az.Osp. Universitaria "Ospedali Riuniti" — Foggia

Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico — Milan

Università di Modena e Reggio Emilia — Modena

Ospedale Maggiore della Carità — Novara

Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone — Palermo

Fondazione Policlinico Universitario Campus Bio-medico — Rome

Fondazione Policlinico Universitario Agostino Gemelli IRCCS — Rome

Istituto Clinico Humanitas — Rozzano

IRCCS Ospedale "Casa Sollievo della Sofferenza" — San Giovanni Rotondo

Universita Degli Studi di Torino — Torino

Azienda Ospedaliera Universitaria Integrata Verona — Verona

The University of Tokyo Hospital — Bunkyō City

Chiba University Hospital — Chiba

Japan Institute for Health Security National Kohnodai Medical Center — Chiba, Ichikawa

Ehime University Hospital — Ehime, Toon

Fukuiken Saiseikai Hospital — Fukui-shi

National Hospital Organization Kyushu Medical Center — Fukuoka, Fukuoka

Kurume University Hospital — Fukuoka, Kurume

Gifu Municipal Hospital — Gifu, Gifu

Nagano Municipal Hospital — Hanishina-gun

Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital — Hiroshima

Hiroshima University Hospital — Hiroshima

Japan Community Health Care Organization Hokkaido Hospital — Hokkaido, Sapporo

Hyogo College of Medicine Hospital — Hyogo, Nishinomiya

Tokyo Medical University Ibaraki Medical Center — Ibaraki, Inashiki-gun

Tokai University Hospital — Isehara-shi

Kanazawa University Hospital — Ishikawa, Kanazawa

Shimane University Hospital — Izumo

Kagoshima University Hospital — Kagoshima

Shin-yurigaoka General Hospital — Kanagawa, Kawasaki

St. Marianna University Hospital — Kawasaki-shi

Kagawa University Hospital — Kita-gun

Kobe University Hospital — Kobe

Kumamoto University Hospital — Kumamoto

Kumamoto Shinto General Hospital — Kumamoto

National Hospital Organization Kure Medical Center and Chugoku Cancer Center — Kure

University Hospital Kyoto Prefectural University of Medicine — Kyoto

University of Miyazaki Hospital — Miyazaki

Japanese Red Cross Musashino Hospital — Musashino

Shinshu University Hospital — Nagano, Matsumoto

Nagasaki Medical Center — Nagasaki, Omura

Nara Medical University Hospital — Nara, Kashihara

International University of Health and Welfare Narita Hospital — Narita

Niigata University Medical and Dental Hospital — Niigata

Okayama University Hospital — Okayama

Osaka City University Hospital — Osaka

Oita Cardiovascular Hospital — Ōita

Saga University Hospital — Saga

Osaka Rosai Hospital — Sakai

Seichokai Bell Land General Hospital — Sakai

Sapporo Kosei General Hospital — Sapporo

Sendai Tokushukai Hospital — Sendai

JCHO Shimonoseki Medical Center — Shimonoseki

Iwate Medical University Hospital — Shiwa-gun

Hamamatsu University Hospital — Shizuoka, Hamamatsu

Juntendo University Shizuoka Hospital — Shizuoka, Izunokuni

Suita Hospital — Suita-Shi

The University of Osaka Hospital — Suita-shi

National Hospital Organization Takasaki General Medical Center — Takasaki-shi

Institute of Science Tokyo Hospital — Tokyo

Tokyo Medical University Hospital — Tokyo

Nihon University Itabashi Hospital — Tokyo

Nippon Medical School Hospital — Tokyo, Bunkyo-ku

Toranomon Hospital — Tokyo, Minato-ku

Fujita Health University Hospital — Toyoake-shi

Mie University Hospital — Tsu

Wakayama Medical University Hospital — Wakayama

Yokohama City University Hospital — Yokohama

The Speciality Hospital (TSH) — Amman

Irbid Specialty Hospital — Irbid

Jordan University Hospital — Jordan

Asfendiyarov Kazakh National Medical University — Almaty

Institute of Gastroenterology, Hepatology and Metabolism LLP — Almaty

Hospital Ampang — Ampang

Hospital Universiti Sains Malaysia — Kota Bharu

University Malaya Medical Centre — Kuala Lumpur

Queen Elizabeth Hospital — Putrajaya

Centro de Investigacion Clinica del Pacifico (CICPA) — Acapulco de Juárez

Centro de Investigación y Gastroenterología — Col. Xoco

Instituto de Diabetes, Obesidad y Nutrición S.C. — Cuernavaca

Clinicos Asociados BOCM SC — Mexico City

Centro de Investigación y Gastroenterología — Mexico City

Medical Care and Research — Mérida

Practice Dr Rosa Isela Luna Ceballos — Veracruz

Centro de Alta Especialidad del Estado de Veracruz — Xalapa

Amsterdam UMC Locatie VUMC — Amsterdam

Albert SchweitzerZiekenhuis — Dordrecht

Radboud Universitair Medisch Centrum — Nijmegen

Erasmus Medisch Centrum — Rotterdam

Franciscus Gasthuis — Schiedam

Tweesteden Ziekenhuis, locatie Tilburg — Tilburg

New Zealand Clinical Research (NZCR) — Grafton, Auckland

Middlemore Hospital — Papatoetoe, Auckland

Christchurch Hospital — Christchurch, Canterbury

Waikato Hospital — Hamilton, Waikato Region

Medical Centre FutureMeds Krakow — Krakow

Santa SP. z o.o — Lodz

FutureMeds Lodz — Lodz

Uniwersytecki Szpital Kliniczny Nr 1 W Lublinie — Lublin

ID Clinic — Mysłowice

FutureMeds Warszawa Centrum — Warsaw

Bodyclinic sp. z o.o. sp.k. — Warsaw

FutureMeds Wroclaw — Wroclaw

EMC Instytut Medyczny S.A. - Wroclaw — Wroclaw

Klinical Investigations Group, LLC — San Juan

Latin Clinical Trial Center — San Juan

FDI Clinical Research — San Juan

Arensia Clinics S.R.L. — Bucharest

Cluj Napoca Clinical County Hospital — Cluj-Napoca

Regional Institute of Gastroenterology Hepatology "Prof. Dr. O. Fodor" — Cluj-Napoca

Spitalul Clinic Judetean De Urgenta Craiova — Craiova

Gastromedica Srl — Iași

Spital Judetean De Urgenta Satu Mare — Satu Mare

King Faisal Specialist Hospital and Research Center — Riyadh

King Abdulaziz Medical City, National Guard Health Affairs — Riyadh

National University Hospital — Singapore

Singapore General Hospital — Singapore

Changi General Hospital — Singapore

Lenasia Clinical Trial Centre — Johannesburg

Charlotte Maxeke Johannesburg Academic Hospital — Johannesburg

Inspired GI Care — Plumstead

Soon Chun Hyang University Hospital Bucheon — Bucheon-si

Pusan National University Hospital — Busan

Yeungnam University Medical Center — Deagu

Inha University Hospital — Incheon

Seoul National University Hospital — Seoul

Asan Medical Center — Seoul

SMG-SNU Boramae Medical Center — Seoul

Korea University Guro Hospital — Seoul

Samsung Medical Center — Seoul

Chung-Ang University Hospital — Seoul

Yonsei University Wonju Severance Christian Hospital — Wŏnju

Complejo Hospitalario Universitario A Coruña — A Coruña

Hospital Universitari Vall d'Hebron — Barcelona

Hospital Universitario Reina Sofía — Córdoba

Hospital Universitario 12 de Octubre — Madrid

Hospital Puerta de Hierro — Majadahonda

Complexo Hospitalario Universitario de Pontevedra — Pontevedra

Hospital Universitario Marqués de Valdecilla — Santander

Hospital Clínico de Santiago — Santiago de Compostela

Fondazione Epatocentro Ticino — Arzo

University Hospital Bern — Bern

Hopitaux Universitaires de Geneve (HUG) — Geneva

University Hospital Zurich — Zurich

Changhua Christian Hospital — Changhua

E-Da Hospital — Kaohsiung City

Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsuing City

Chung Shan Medical University Hospital — Taichung

Taichung Veterans General Hospital — Taichung

National Cheng Kung University Hospital — Tainan

Chi Mei Medical Center — Tainan

National Taiwan University Hospital — Taipei

Taipei Medical University Hospital — Taipei

Taipei Veterans General Hospital — Taipei

Chang Gung Medical Foundation (CGMF) - Linkou Bran — Taoyuan

Ankara Üniversitesi Tıp Fakültesi Hastanesi — Ankara

Gazi Universitesi Tip Fakultesi — Ankara

Uludag Universitesi Tip Fakultesi — Bursa

Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi — Fatih

Koc Universitesi Hastanesi — Istanbul

Memorial Bahçelievler Hospital — Istanbul

Ege Universitesi Tip Fakultesi — Izmir

Recep Tayyip Erdogan Universitesi Egitim ve Arastirma Hastanesi — Rize

Aberdeen Royal Infirmary — Aberdeen

Elpida Clinical Trials - Ashton Clinic — Ashton in Makerfield

Velocity Clinical Research, Bristol — Bristol

Frimley Park Hospital — Camberley

Queen Elizabeth Hospital Birmingham — Edgbaston, Birmingham

Elpida Clinical Trials - Edgware Community Hospital — Edgware

Panthera Biopartners - Enfield — Enfield, London

Royal Devon and Exeter Hospital, Wonford — Exeter

Panthera Biopartners - Glasgow — Glasgow

Hull Royal Infirmary — Hull

Royal Free Hospital — London

King's College Hospital — London

Chelsea and Westminster Hospital — London

Newcastle General Hospital — Newcastle upon Tyne

Accellacare North London — Northwood

Queen's Medical Centre — Nottingham

Accellacare - South London — Orpington, London

Panthera Biopartners - Preston — Preston

Panthera Biopartners - Rochdale — Rochdale

Panthera Biopartners - Sheffield — Sheffield

Southampton General Hospital — Southampton

St George's Hospital — Tooting, London

Panthera Biopartners - York — York

Contact

Boehringer Ingelheim

[email protected]

Phone

1-800-243-0127

Experimental Treatment

This trial is testing a new treatment. Results are not guaranteed. Talk to your doctor before applying.

Apply to This Trial

Your information will be sent to the study coordinator for review.